Africa’s young, tech-savvy population, rising NCD burden, and climate threats are driving demand for digital health innovation. Opportunities lie in leapfrogging legacy systems, adopting open-source solutions, and fostering pan-African collaboration. Yet challenges persist: private/public funding gaps, underdeveloped EHR systems, uneven mobile health adoption, and limited scalability of pilots. Rwanda stands out with strong government commitment, early EHR rollout, and community health worker programs. To succeed, Africa must build sustainable financing, expand open-source mHealth, and implement future-fit systems that address both infectious and chronic diseases.

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