This report quantifies the incidence, clinical burden, and economic impact of post-COVID-19 conditions using real-world evidence and global modeling. It defines post-COVID conditions as a broad, multi-organ syndrome affecting patients weeks or months after infection. Based on claims data and literature, the report estimates that at least 22% of diagnosed COVID-19 patients experience post-COVID conditions, with nervous, respiratory, and cardiovascular systems most affected. Globally, hundreds of millions of cases may exist, including undiagnosed “shadow” patients. The report estimates significant therapeutic costs and emphasizes the need for further research and coordinated care strategies.

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