L.E.K. Consulting’s 2025 U.S. healthcare forecast highlights a sector at a turning point, balancing financial strain, regulatory shifts, and innovation. Hospitals face declining margins and rising acuity, while virtual care and precision medicine expand. Payers must adapt to Medicare Advantage instability, Medicaid disenrollments, and rising drug costs. GLP-1 coverage and ICHRA enrollment are poised to grow. In tech, HCIT providers move toward integrated suites, and generative AI is adopted mainly for administrative use. Private equity activity is rebounding amid easing interest rates. The year demands resilience, innovation, and cross-sector collaboration.

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