Using Spark Reagent Databases to Find the Next Move R. Lawrence † , T. Cheeseright † , M. Slater † † Cresset, New Cambridge House, Bassingbourn Road, Litlington, Cambridgeshire, SG8 0SS Abstract Cresset’s Spark software was used to investigate new R groups that could be used to grow a fragment- like inhibitor of p38. The use of databases derived from available reagents ensured that the results could be tethered to molecules that were read

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