Deciphering Complex SAR T. Cheeseright † † Cresset, New Cambridge House, Bassingbourn Road, Litlington, Cambridgeshire, SG8 0SS, UK Abstract The substitution of aromatic groups provides a unique tool to moderate the potency and physicochemical properties of drug like molecules. However, the huge variety of substitutions that are possible can give rise to SAR that is almost impossible to understand, with small changes resulting in large

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