CASE STUDY | NANOCRYSTALIZATION Ultrasonic Nanocrystallization of Nifedipine for Improved Drug Delivery (646) 580-4676 contact@sonomechanics.com Many biologically active compounds (e.g., drugs and nutraceuticals) exhibit poor water solubility, which complicates their delivery to the blood stream and reduces the associated bioavailability. Top-down nanocrystallization (particle size reduction to the nanometer range) of these substances increases their aqueous dissolution rate and solubility, which results in improved bioavailability, accelerated onset of action, and decreased potential of harmful side-effects. Allied Innovative Systems (ALLIS) partnered with Industrial Sonomechanics (ISM) in order to determine the effectiveness of the high-amplitude ultrasonic nanocrystalliz

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