Insight. Innovation. Transformation. White Paper Introduction For some time now, there has been a broad agreement that social determinants of health (SDoH) highly influence how individuals interact (or don’t) with the healthcare system which, in turn, impacts health outcomes. Researchers believe as much as 80% of the contributors to healthy outcomes are SDoH-related, such as nonclinical factors like behavior, socioeconomics, financial and health literacy, race, and ethnicity. 1 Researchers, clinicians, care management teams, and life sciences firms have been exploring SDoH for some time now; but results have been decidedly mixed. 2 That begs the questions, under what circumstances does SDoH actually help improve therapeutic effectiveness or increase adherence? Or help address

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