Introduction Clean-in-place (CIP) is a method of cleaning the interior surfaces of pipes, vessels, process equipment, filters and associated fittings without disassembly. The CIP system is run by digital computer called programmable logic controllers (PLCs) to control the flow, temperature, and time for the chemical solutions, which could be acidic, alkaline or sometimes both, to achieve maximum cleaning. The chemical solutions are circulated through a circuit of tanks and/or lines to eliminate contaminants or product residues and are rinsed out with water. Depending on the CIP system, chemical solutions may flow back to a reservoir so that they can be re-used or drained immediately after they have been used. After CIP, the equipment should be visibly clean and free fro

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