White Paper Authors George W. Rogers, Lisa Winer, Melanie Schwalfenberg, Natalia Romero, and Yoonseok Kam Agilent Technologies, Inc. Abstract Agilent Seahorse XF analyzers are used to study cellular metabolism in a diverse array of research areas, including assessment of drug-induced mitochondrial toxicity. Direct measurement of mitochondrial oxygen consumption can be used as a specific and sensitive indicator to assess drug-induced mitochondrial toxicity, a common issue in therapeutic development. This white paper establishes a customized XF assay solution for the detection of mitochondrial toxicity using standardized parameters. The solution includes the following key features: – The ability to both identify and distinguish among different modes of mitochondrial toxicity

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