Discovery of KYM-003, a potent and selective STAT3 degrader with anti-tumor Case Study
Discovery of KYM-003, a potent and selective STAT3 degrader with anti-tumor Case Study
1 PagesSTAT3 is a transcription factor downstream of several signaling events including the RT-PCR in SU-DHL-1 cells, 24hr Viability, CellTiterGlo, 4 days IL-6/JAK pathway. Activating mutations and aberrant activation of STAT3 drive a subset of tumors via induction of autocrine factors that promote tumor proliferation and survival, as well as induction of proteins that may contribute to a tumor permissive environment.
