Discovery of potent and selective STAT3 targeted protein degraders with excellent in vitro and in vivo ADME properties Case Study
Discovery of potent and selective STAT3 targeted protein degraders with excellent in vitro and in vivo ADME properties Case Study
17 PagesSTAT3 is a traditionally largely undrugged transcription factor activated through cytokine and growth factor receptors via JAKs and non-JAKs mediated mechanisms. High degree of validation of JAK-STAT pathway in oncology and immuno-oncology supported also by numerous publications. STAT3 plays a role in tumor biology, evasion of immune surveillance and inflammation/fibrosis.
