Determination of Isotopic Purity by Accurate Mass LC/MS Authors: Dr Alan Thompson, Dr Osama Chahrour and Dr John Malone CASE STUDYFollowing the synthesis of isotopic labelled APIs at Almac, or stability testing, it is often necessary to accurately determine the isotopic enrichment of the compounds by mass spectrometry. This process is often complicated if the compound in question contains a variety of labelled atoms, including C, N and H

Join for free to read