Introduces enriched study methods that combine primary and secondary data to generate more efficient, robust real-world evidence. Demonstrates benefits like reduced burden on sites and patients, streamlined operations, and enhanced scientific insights. Case studies in diabetes, back pain, COVID-19, and kidney disease showcase applications. Emphasizes secure patient-level linkage, compliance with regulatory frameworks, and the potential of interoperability. Argues that enriched approaches lower costs while delivering richer, more actionable evidence for healthcare decisions.

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