This white paper focuses on improving patient recruitment and retention in obesity clinical trials through patient-centric engagement. Drawing on behavioral science and real-world trial experience, it explores the emotional, social, and practical barriers faced by people living with obesity. The paper advocates for incorporating patient voice, personalization, and holistic support services throughout the trial journey. Strategies include tailored communications, site training, nutritional counseling, and digital engagement tools. The analysis concludes that a motivating engagement ecosystem is critical to trial success in an increasingly competitive obesity research landscape.

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