Master protocols—basket, umbrella, and platform trials—are accelerating drug development by combining adaptive design, shared infrastructure, and real-time data use. They enable faster decisions, cost savings, and broader patient access, particularly in high-need areas like oncology. Success depends on three pillars: strategic decision-making, early regulatory engagement, and operational excellence, supported by centralized governance, interoperable systems, and stakeholder collaboration. CRO partnerships are critical to navigate complexity, ensure compliance, and manage evolving trial needs. With flexibility, these designs shorten timelines, improve patient focus, and maximize ROI.

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