This paper explains how healthcare organizations rely on APIs to exchange patient data, support telemedicine, and enable interoperability, making the protection of electronic protected health information essential. It outlines a compliance landscape shaped by HIPAA requirements for privacy and technical safeguards, GDPR obligations for EU personal data, ISO/IEC 27001 and 27017 guidance for securing cloud-based data, and the MITRE ATT&CK framework for understanding API-specific threats. Key security needs include encrypting ePHI in transit and at rest, enforcing strict access controls and audit trails, ensuring data integrity, and performing regular risk assessments. The paper emphasizes API posture governance as critical to maintaining continuous compliance, preventing misconfigurations, a

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