This paper explains ISO/IEC 42001, the first global standard for an Artificial Intelligence Management System, and shows why strong API governance is essential to responsible and secure AI. Although not an API security standard, ISO 42001 emphasizes lifecycle governance, risk management, and data governance, all of which rely heavily on APIs as the primary interfaces to AI systems. Insecure APIs are identified as a major risk vector that can enable model theft, data poisoning, unauthorized access, and integrity loss. The standard calls for encrypted data channels, strict authentication and authorization, continuous monitoring, and accountability across the full AI lifecycle, positioning robust API security as a foundational requirement for compliant, trustworthy AI operations.

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