This paper outlines how IEC 62443 addresses the security of industrial automation and control systems that rely on APIs to operate critical infrastructure. It emphasizes a zone and conduit model that segments industrial networks and enforces secure communication paths to limit unauthorized access and lateral movement. The standard requires strong authentication, such as mutual TLS, and granular role-based access control to protect sensitive industrial functions, while accounting for real-time constraints and legacy systems common in operational technology environments. By securing APIs that connect industrial systems, IEC 62443 helps reduce disruption risks, protect safety, and maintain the reliability and continuity of essential industrial operations.

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