Product Quality Improved by Reducing Segregation The Need Particle segregation or demixing is a major concern, especially in the pharmaceutical industry, where only very slight variations in the concentration of active drug are permitted. Drugs that are produced in solid dosage form (i.e., tablets and capsules), contain many ingredients. If the active ingredient is not uniformly distributed, the finished product will not fall within content uniformity specifications and the entire batch may be rejected. A leading pharmaceutical firm was in the process of validating a new tablet product, which begins with several ingredients being added to a tumble blender. The blended material is then discharged into multiple bins. Initial tests during scale-up showed high active ingredient percentages

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