RESEARCH Open Access Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial—PROSPECT: a pilot trial Deborah J. Cook 1,2* , Jennie Johnstone 3,4,5 , John C. Marshall 6,7 , Francois Lauzier 8,9,10 , Lehana Thabane 2 , Sangeeta Mehta 5,7 , Peter M. Dodek 11,12 , Lauralyn McIntyre 13 , Joe Pagliarello 13 , William Henderson 14 , Robert W. Taylor 15 , Rodrigo Cartin-Ceba 16 , Eyal Golan 5,7 , Margaret Herridge 5,7 , Gordon Wood 17 , Daniel Ovakim 17 , Tim Karachi 1 , Michael G. Surette 1 , Dawn M. E. Bowdish 18 , Daphnee Lamarche 19 , Chris P. Verschoor 18 , Erick H. Duan 1 , Diane Heels-Ansdell 2 , Yaseen Arabi 20 , Maureen Meade 1,2 and For the PROSPECT Investigators and the Canadian Critical Care Trials Group Abstract Background: Probiotics are live microorganisms tha

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