Using Cloud to Fight Nicotine Addiction 2 Copyright © 2019, Oracle and/or its affiliates. All rights reserved. • Smoking is the second most common cause of death globally 1 (~5 million deaths annually) and remains a major public health issue • ~86% of lung cancer caused by tobacco • 25% of the world’s population smokes 2 • Most anti-smoking drugs are only moderately effective in reducing symptoms of withdrawal and may cause undesirable side-effects (nausea, headaches, etc.) • Nicotine is the major psychoactive agent in tobacco, causing addiction and binds mainly to a4ß2 nAChR 3 (nicotine receptor in the brain) 1. “The health consequence of smoking: nicotine addiction”, CDC, 1988 2. “World Cancer Report 2014”, WHO, 2014 3. Dineley et al (2015) Trends Pharmacol Sci 36:96-108 Oracle Clou

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