Hyperekplexia and stiff person syndrome can be caused by defects of human glycine receptors, an anionic ligand-gated ion channel. These receptors are found in all the animal kingdom, activated by a diversity of molecules. Understanding how they work in any species will provide insight for the others. The comparison study between two glutamate-gated chloride channels that present a different pharmacology from C. elegans, a nematode, and Apl

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