Case Study: Novel Application for Monitoring Interstitial Fluid Pressure in Glioblastoma Mouse Model Introduction Cancer remains the second leading cause of death worldwide. Glioblastoma (GBM), the most common primary brain tumor, develops as a solid tumor(s) and is considered the most aggressive type of brain cancer, with an average life expectancy between 12-15 months. Many factors contribute to the increased difficulty in treating brain tumors, including the blood brain barrier and increased interstitial fluid pressure (IFP). While the blood brain barrier limits the types of compounds able to cross into the brain, increased pressure in the interstitial fluid surrounding GBM and other types of solid tumors has been found to decrease the uptake of anti-tumor treatments. A

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