Glaxo Smith Kline, King of Prussia PA Dennis J. Murphy, John Renninger, and Kent Gossett © 2009 Data Sciences International Case Study: Chronic Pleural Pressure Measurement Introduction Pleural pressures are used to evaluate lung function, but have generally been measured acutely and only in anesthetized models [Costa 1985, Murphy 1994]. These direct methods usually involved insertion of a pressure-sensitive probe into the pleural cavity, invariably causing lung damage, and with little potential for chronic measurement. Previous studies indicate that esophageal pressure changes within the thoracic cavity accurately emulate pleural pressure changes [Palecek 1969, Gillespie 1973, Koo 1976]. A study was conducted to determine whether it would be possible to chronically

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