Mechanisms Underlying Synergistic Activity of KT-413, a Targeted Degrader of IRAK4 and IMiD Substrates in Hematopoietic Cancers
Mechanisms Underlying Synergistic Activity of KT-413, a Targeted Degrader of IRAK4 and IMiD Substrates in Hematopoietic Cancers
11 PagesAlternative pathway activation of NF-kB and downregulation of cell death signals is common in MYD88MT lymphoma via activating mutations in CD79B and CARD11, TNFAIP3 loss, or IRF4 upregulation. Inhibiting multiple pathways of NF-kB activation and survival signaling may be necessary to drive cell death in MYD88MTlymphomas.
