KTX-120, A Novel IRAKIMiDDegrader of IRAK4 and IMiD Substrates, Shows Preferential Activity and Induces Regressions
KTX-120, A Novel IRAKIMiDDegrader of IRAK4 and IMiD Substrates, Shows Preferential Activity and Induces Regressions
9 PagesPotent, preferential activity in MYD88MTDLBCL cell lines. Rapid onset of cell death -commitment to death within 48-72h. Superior cell activity compared to the IMiDCC-220 in MYD88MTDLBCL cell lines. Tumor regressions in multiple MYD88MTCDX and PDxmodels in both PO and IV schedules with intermittent dosing.
