By Dr. Piet van der Graaf, SVP Leveraging Biosimulation to Inform Optimal Use of COVID-19 Vaccines2 Leveraging Biosimulation to Inform Optimal Use of COVID-19 Vaccines As the world struggles to address the vast demand for, and limited supply of, regulatory-approved COVID-19 vaccines, experts are investigating scientific approaches to maximize those precious resources. Biosimulation, which integrates computer-aided modeling and simulation with pharmaceutical science, provides potent intelligence to support decision making on these crucial issues. It can help answer questions like: • Do elderly people require a higher dose of the COVID-19 vaccine because their immune system becomes less effective with age? • Might a lower vaccine dose be effective for young people? • Can the in

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