Supporting organisations in gaining value from process understanding Con t a c t +44(0)1925 607030 enquiries@britest.co.uk www.britest.co.uk Challenge Pressure filtration is one of the most commonly used isolation techniques used in the manufacture of pharmaceuticals and fine chemicals. Consequently, AZ has built up a body of experience and understanding in this important area. This can however often be overlooked during process development and, as a result, issues such as slow filtration, polymorph change, particle size erosion, and blockages may be encountered on scale up. These can result in lengthy delays during manufacture, costing tens of thousands of $ per day. More importantly, API quality can be at risk, potentially resulting in failure to meet specification. App

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