White Paper Authors Lakshmi Subbarao, Megan Kenny, and Linda Lloyd Agilent Technologies, Inc. Introduction The benefits of analytical columns packed with superficially porous particles (SPPs) are well known. 1 A superficially porous particle consists of a solid silica core that is covered by a porous shell. This creates a shorter diffusion path for an analyte, providing chromatographic speed and efficiency advantages over totally porous particles (TPPs). Recently, Agilent introduced the InfinityLab Poroshell 120 preparative LC column, the first preparative column packed with 4 µm SPP particles. These columns bring the SPP advantages to a larger scale, while still using standard preparative HPLC instrumentation. The value of SPP-packed columns stands out in high-throughput environ

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