Eliminating Granulation Blend Flow and Segregation Problems The Need A pharmaceutical company was producing tablets from a granulation and did not experience flow or segregation problems during process development and validation. However, increased demand with the product required either faster press speeds or a secondary tableting press. The granulation had low segregation tendencies, but, it also flowed poorly through containers and press hoppers. Jenike & Johanson was contacted to assist in determining the cause of the problems and to recommend a solution. The Solution While on-site at the plant, Jenike & Johanson engineers observed funnel flow discharge with the granulation in both the container and press hopper. Eventually, a rathole formed in each component, thereby requiring opera

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