Case Study

Effect Of Anti-Drug Antibodies

Effect Of Anti-Drug Antibodies

Pages 2 Pages

Abstract Purpose: 1) To investigate incurred sample reanalysis (ISR) failure for a preclinical study; 2) To investigate possible effect of generated anti-drug antibodies on ISR results. Methods: Enzyme Linked Immunosorbent Assay (ELISA) and bridging Electrochemiluminescence (ECL) methods were used for quantification of analyte and determination of ADA in study samples, respectively. Results: 1) Original ISR analysis was performed and the ISR

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