Combining Cellular Bioenergetics with Metabolomics Reveals Nutrient Competitive Pathways for Anticancer Therapies Agilent case study: Dr. Costas Lyssiotis "Survival of the fittest" is a foundational principle in biology; Charles Darwin himself used the phrase to describe organisms that are better designed to live and thrive in the environment they inhabit. For researchers studying the biochemistry of cancer, the phrase has particular relevance. Just as a pack of wolves might compete with other nearby packs for access to prey, cancer cells compete with the healthy cells around them for access to nutrients and other resources necessary for their survival. Dr. Costas Lyssiotis, whose research focuses on metabolism in tumor cells – particularly, pancreatic tumors – looks for ways to

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