1 Life Sciences Manufacturing Case Studies Life Sciences Manufacturing Case Study Highlights2 Life Sciences Manufacturing Case Studies SITUATION SOLUTION VALUE DELIVERED • Process understanding and optimization of mammalian cell cultures is reliant on online and offline measurements • Two projects were initiated to evaluate the online process mass spectrometry • One of the cell lines was a GS-CHO producing lgG4 monoclonal antibody (mAb) • Precision of the Thermo ScientificTM Prima BT Bench Top Mass Spectrometer was 50x greater for both CO2 and O2, and drift between calibration was eliminated • When monitoring 12 fermenters the price of the mass spectrometer was equivalent to the low performance sensors • High precision and speed analysis • Better process understanding • RQ

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