This paper outlines 2024–2025 updates to HIPAA rules, increased penalties, breach-reporting expectations, and requirements for data integrity, retention, and auditability. It explains how modern healthcare environments face threats such as ransomware, insider misuse, EHR corruption, and legacy systems. The guide stresses the need for immutable backups, rapid restoration, encryption, access controls, and detailed audit trails to satisfy HIPAA’s Security Rule and Privacy Rule. It highlights how organizations can reduce compliance risk, safeguard PHI, and maintain clinical continuity through resilient data-protection practices.

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