This white paper highlights the critical role of data interoperability in decentralized clinical trials (DCTs). With the rise of Digital Health Technologies and patient-sourced data, seamless integration across diverse systems is essential for real-time insights, regulatory compliance, and study integrity. It emphasizes using intelligent rules engines, open APIs, and interoperability platforms to harmonize complex data streams from EDCs, CTMS, wearables, and more. Adaptive Clinical Systems’ tools enable flexible, secure, and compliant data exchange to support efficient, high-volume clinical trials.

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