This white paper examines blood pressure variability (BPV) as a critical but often underappreciated cardiovascular risk factor in clinical research. It explains short-term, mid-term, and long-term BPV and their associations with cardiovascular morbidity, mortality, and end-organ damage. The document highlights limitations of single time-point blood pressure readings and emphasizes the value of continuous and ambulatory monitoring to capture true variability. Methodological considerations for BPV measurement in clinical trials are discussed, including device selection, standardized protocols, and data interpretation. The paper also outlines how centralized, high-quality BP data collection can improve signal detection, reduce noise, and support regulatory confidence, particularly in hyperten

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