Introduction Charles River Laboratories (CRL) is a long-time user of Data Sciences International’s (DSI) implantable telemetry, and currently use the D70-PCTR implant in their large animal safety pharmacology studies. In 2019, DSI introduced the L11R device for the PhysioTelTM Digital platform as a replacement to the D70-PCTR. The objective of this study was to benchmark and validate the respiratory signal data from the L11R to signals collected from current industry standards. The Background Safety pharmacology is a branch within drug development that assesses the potential adverse pharmacodynamic effects of a compound within and above the therapeutic range on physiological functions. Monitoring and evaluating the safety of a compound on the central nervous

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