Case Study
Structural Characterization of an Antibody in Complex With a Serine Protease
accelrys.com CASE STUDY 1 Structural stabilization due to monoclonal antibody binding influences the protease activity of human kallikrein-3 • A c cur a t e pr ot ein-pr ot ein c omple x struc tur e pr edic tion and r efinemen t with ZDOCK and RDOCK pr ot oc ols • CHARM m based C alcula t e M uta tion Ener gy pr ot oc ol pr edic ts an tibody mutan ts with enhanc ed stabilit y Structural characterization of an antibody in c omplex wi