Conclusion ? Accucore, a fused core column, provides added mechanical stability in a 2D chromatographic environment prone to pressure spikes which affects traditional columns. As a results background pressure and analyte response display increased stability. ? The novel transfer step, with its 2 stage transfer provides for a cleaner extract. As a result, the analytical column experiences less contamination as seen by lower pressure increase over time. ? The MS improvements, both in terms of the new S-lens and the polarity switch after each acquisition combine to keep the system cleaner for longer periods, even with pooled human samples. ? When combined, these improvements have effectively increased the assay stability from 400 injections to 1200. This study was performed

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