If the interaction of clotting factors in the blood is not functioning properly, the clotting may be too strong (thrombosis) or too weak (spontaneous bleeding). The role of the thrombin enzyme in the conversion of the fibrinogen clotting factor into fibrin was discovered at Maastricht University. In the event of damage to a blood vessel, fibres from that protein form a network that can ‘capture’ platelets whereby a clot is created that seals

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