Pharmaceutical Application: Eye Drop Production Customer Requirement The production of eye drops requires periodic sterilization of the bottle filling station with careful monitoring of the steam used for sterilization. The bottle filling station uses 20 nozzles to fill a progressive line of plastic bottles. Periodically, the nozzles are lowered into the sterilization chambers located directly below the station. Here the nozzles are exposed to steam to sterilize them. In this SIP (sterilize in place) application, the environment to be measured consists of 80o C purified water followed by 123o C clean steam at 20 psi for 30 minutes. The customer had to ensure that the sterilization process kept the equipment at 123o C for 30 consecutive minutes. The customer was experiencing problems with

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