Japanese Pharmaceutical Company Improves Quality with Aspen Plus Case Study ®CHALLENGE • Scale up production of a new active pharmaceutical ingredient (API) while improving the purity of the product. SOLUTION Aspen Plus provided an in-depth understanding of a new API process leading to equipment improvements and optimized recipes that enabled development of a continuous process. BENEFITS Aspen Plus delivered multiple benefits: • impurities decreased from 500 ppm to 20 ppm • crystallization time dropped from 8 hours with a batch process to just 20 minutes with a continuous process • shorter research and development time for the new API Reduction in Crystallization Time and Impurity Production 96% A 140-year-old global pharmaceutical company with headquarters in Japan adopted As

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