Effect of decision aid for breast cancer prevention on decisional conflict in women with a BRCA1 or BRCA2 mutation: a multisite, randomized, controlle
Effect of decision aid for breast cancer prevention on decisional conflict in women with a BRCA1 or BRCA2 mutation: a multisite, randomized, controlle
7 Pages330 Original r esearch a rticle © American College of Medical Genetics and Genomics INTRODUCTION For women who carry a mutation in BRCA1 or BRCA2, the risk of developing breast cancer is estimated to be as high as 80% by the age of 70 (ref. 1). Strategies to reduce the risk include prophylactic surgery (oophorectomy and/or mastectomy) and chemoprevention (tamoxifen). Each of these options has a dif- ferent impact on breast cancer risk and a unique risk/benefit profile. As a result, decisions about breast cancer risk reduction can be difficult. No single choice will satisfy all of a woman’s personal objectives because no alternative is without residual risk of cancer and each has undesired outcomes. This situation is known as “choice dilemma” or “conflicted decision. ” 2 For women
