Randomization and the management of trial supplies is a critical factor in clinical research. In this white paper we review several major randomization approaches currently used in clinical trials. We also describe the dynamic central randomization (DCR) method that was defined, tested and implemented as part of Datatrak ’s eClinical solution. The new method was designed to achieve balance at the study level and the site (center) level as well. Different from other randomization methods, DCR takes into account the inventory conditions and supply management to re

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