Discovery-driven development of mass spectrometry methods for food allergen detection and quantification individuals must follow strict avoidance diets. A critical part of being able to avoid a food of concern is getting clear and accurate information about what food allergens are present in foods. Accordingly, many regulatory authorities have implemented mandatory labeling requirements for major food allergens, or ingredients derived from thereof, when used as intentional ingredients. In the U.S., the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA) mandates that the following eight allergenic foods, which are responsible for an estimated 90% of food allergies, be listed in plain English on the label of FDA-regulated packaged foods: peanuts, tree nuts, soy,

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