European Journal of Heart Failure (2017) 19, 579–587 STUDY DESIGN doi:10.1002/ejhf.790 Design of the effect of adaptive servo-ventilation on survival and cardiovascular hospital admissions in patients with heart failure and sleep apnoea: the ADVENT-HF trial Owen D. Lyons 1 ,JohnS.Floras 2 , Alexander G. Logan 2 , Robert Beanlands 3 , Joaquin Durán Cantolla 4 , Michael Fitzpatrick 5 , John Fleetham 6 ,R.JohnKimoff 7 , Richard S.T. Leung 8 , Geraldo Lorenzi Filho 9 , Pierre Mayer 10 , Lisa Mielniczuk 3 , Debra L. Morrison 11 , Clodagh M. Ryan 2 , Frederic Series 12 , George A. Tomlinson 2 , Anna Woo 2 , Michael Arzt 13 , Sairam Parthasarathy 14 , Stefania Redolfi 15 , Takatoshi Kasai 16 , Gianfranco Parati 17 , Diego H. Delgado 2 ,and T. Douglas Bradley 2 *, for the ADVENT-HF Investigators †

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