White Paper Authors Dr. Emre Türeli MyBiotech Dr. Karen Krauel-Göllner Agilent Technologies, Inc. Introduction One of the major challenges in modern drug development is the poor aqueous solubility of many drug candidates. Nanoparticle formulations are an attractive solution to increase the bioavailability of drugs with low aqueous solubility. Dissolution studies are one of the most important methods used to characterize the expected in vivo bioavailability under in vitro conditions. Thus, an efficient dissolution method is necessary during the nanoparticle development process to facilitate the selection of lead formulations with an expected higher bioavailability. It is equally important for quality control purposes during later stages of the product life cycle. Therefore, the s

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